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Choose with enough water to ensure full swallowing; do not pre-soak, lick or usually soaked ahead of swallowing.Concomitant utilization of CYP450 3A4 inducers or inhibitors may involve dose adjustment: Check with drug interactionsCrCl a lot less than 60 mL/moment: Start off conservatively which has a lower than normal dose; titrate diligently to id